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Listar por autor "García Rubio, María Luisa"
Mostrando ítems 1-20 de 31
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Artículo
A genome-wide function of THSC/TREX-2 at active genes prevents transcription–replication collisions
Santos Pereira, José María; García Rubio, María Luisa; González Aguilera, Cristina; Luna Varo, Rosa María; Aguilera López, Andrés (Oxford University Press, 2014)The THSC/TREX-2 complex of Saccharomyces cerevisiae mediates the anchoring of transcribed genes to the nuclear pore, linking ...
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A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs
García Muse, Tatiana; Galindo Díaz, U.; García Rubio, María Luisa; Martin, Julie S.; Polanowska, Jolanta; O'Reilly, N.; Aguilera López, Andrés; Boulton, Simon J. (Elsevier B.V., 2019)Accurate meiotic chromosome segregation critically depends on the formation of inter-homolog crossovers initiated by ...
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A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination
Muñoz Galván, Sandra; García Rubio, María Luisa; Ortega Moreno, Pedro; Ruiz Pérez, José Francisco; Jimeno González, Sonia; Pardo, Benjamín; Gómez González, Belén; Aguilera López, Andrés (Public Library of Science, 2017)Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to ...
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Artículo
A role for the Saccharomyces cerevisiae Rtt109 histone acetyltransferase in R-loop homeostasis and associated genome instability
Cañas, Juan Carlos; García Rubio, María Luisa; García, Alicia; Antequera, Francisco; Gómez González, Belén; Aguilera López, Andrés (Genetics Society of America, 2022)The stability of the genome is occasionally challenged by the formation of DNA-RNA hybrids and R-loops, which can be ...
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An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination
Huertas Sánchez, Pablo; García Rubio, María Luisa; Wellinger, Ralf Erik; Luna Varo, Rosa María; Aguilera López, Andrés (American Society for Microbiology, 2006)THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. ...
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C. elegans THSC/TREX-2 deficiency causes replication stress and genome instability
Zheleva, Angelina; Pérez de Camino Cantos, Dolores; Fernández Fernández, Nuria; García Rubio, María Luisa; Askjaer, Peter; García Muse, Tatiana; Aguilera López, Andrés (The Company of Biologists, 2021)Transcription is an essential process of DNA metabolism, yet it makes DNA more susceptible to DNA damage. THSC/TREX-2 is ...
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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
Marchena Cruz, Esther; Camino, Lola P.; Bhandari, Jay; Pinela Da Silva, Sonia Cristina; Marqueta Gracia, José Javier; Amdeen, Shahad A.; Guillén Mendoza, Cristina; García Rubio, María Luisa; Calderón Montaño, José Manuel; Xue, Xiaoyu; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2023)Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic ...
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Capítulo de Libro
Detection of DNA-RNA hybrids in vivo
García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Humana Press Inc., 2018)DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they ...
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Artículo
Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening
Gavaldá Martín, Sandra; Santos Pereira, José María; García Rubio, María Luisa; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2016)Yra1 is an essential nuclear factor of the evolutionarily conserved family of hnRNP-like export factors that when overexpressed ...
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Artículo
FANCD2 facilitates replication through common fragile sites
Madireddy, Advaitha; Aguilera López, Andrés; Herrera Moyano, Emilia; García Rubio, María Luisa; Owen, Nichole; Olson, Susan (Elsevier, 2016)Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the ...
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Artículo
Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair
Gaillard, Hélène; Tous Rivera, Cristina; Botet, Javier; González Aguilera, Cristina; Quintero, María José; Viladevall, Laia; García Rubio, María Luisa; Rodríguez Gil, Alfonso; Marín, Antonio; Ariño, Joaquín; Revuelta, José Luis; Chávez de Diego, Sebastián; Aguilera López, Andrés (Public Library of Science, 2009)RNA polymerases frequently deal with a number of obstacles during transcription elongation that need to be removed for ...
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Artículo
Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner
Lafuente Barquero, Juan; García Rubio, María Luisa; San Martín Alonso, Marta; Gómez González, Belén; Aguilera López, Andrés (eLife Sciences Publications, 2020)DNA:RNA hybrids constitute a well-known source of recombinogenic DNA damage. The current literature is in agreement with ...
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Artículo
Harmful R-loops are prevented via different cell cycle-specific mechanisms
San Martín Alonso, Marta; Soler Oliva, María Eugenia; García Rubio, María Luisa; García Muse, Tatiana; Aguilera López, Andrés (Springer Nature, 2021)Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by ...
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Histone Mutants Separate R Loop Formation from Genome Instability Induction
García Pichardo, Desiré; Cañas, Juan C.; García Rubio, María Luisa; Gómez González, Belén; García Rondón, Ana; Aguilera López, Andrés (Elsevier, 2017)R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms ...
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Artículo
Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae
Chávez de Diego, Sebastián; García Rubio, María Luisa; Prado Velasco, José Félix; Aguilera López, Andrés (American Society for Microbiology, 2001)Hpr1 forms, together with Tho2, Mft1, and Thp2, the THO complex, which controls transcription elongation and genome ...
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Artículo
Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation
García Rondón, Ana; Jimeno González, Sonia; García Rubio, María Luisa; Aguilera López, Andrés (American Society for Biochemistry and Molecular Biology Inc., 2003)THO/TREX is a conserved eukaryotic complex formed by the core THO complex plus proteins involved in mRNA metabolism and ...
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Artículo
Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
Duch, Alba; Barroso Ceballos, Sonia Inés; García Rubio, María Luisa; Seisenbacher, Gerhard; Aguilera López, Andrés (Nature Publishing Group:, 2018)Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have ...
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Artículo
New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation
Jimeno González, Sonia; Tous Rivera, Cristina; García Rubio, María Luisa; Ranes, Michael; González Aguilera, Cristina; Marín Rodríguez, Antonio; Aguilera López, Andrés (American Society for Microbiology, 2011)Formation of a ribonucleoprotein particle (mRNP) competent for export requires the coupling of transcription with mRNA ...
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Artículo
Nucleoporins prevent DNA damage accumulation by modulating Ulp1-dependent sumoylation processes
Palancade, Benoit; Liu, Xianpeng; García Rubio, María Luisa; Aguilera López, Andrés; Zhao, Xiaolan; Doye, Valérie (American Society for Cell Biology, 2007)Increasing evidences suggest that nuclear pore complexes (NPCs) control different aspects of nuclear metabolism, including ...
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Artículo
The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Muñoz Sánchez, Sergio; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés (EMBO Press, 2019-07-24)Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ...